There will be no gentle start for the favourites with nine-time winner Rafa Nadal and defending champion Novak Djokovic on a semi-final collision course.
Fourth seed Nadal, who has only lost one match on clay this season, was handed a tricky first-round opponent in the mercurial Benoit Paire
Serbian Djokovic, the second seed, will take on Spain's Marcel Granollers, a man who has won three of his four ATP titles on the red dirt.
Murray faces a potential third-round with either claycourt specialist Nicolas Almagro or Argentine Juan Martin Del Potro.
Third seed Stan Wawrinka of Switzerland, the 2015 champion, will face a qualifier and could meet Murray in the semi-finals.
In the women's draw Czech Petra Kvitova, who has not played competitive tennis since being stabbed during a burglary at her home last December, was included as 15th seed thanks to her protected ranking.
Providing she is fit to play, she will take on American Julia Boserup.
Defending champion Garbine Muguruza was handed a tricky first round as she will take on the 2010 champion, Italian Francesca Schiavone.
On her possible path to the final, the fourth-seeded Spaniard could also face American Venus Williams.
World number one Angelique Kerber will open her campaign against Ekaterina Makarova.
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